SynChrom nucleophilic substitution R&D

R&D synthesis unit for nucleophilic substitution

Almost all synthesis processes can be applied. E.g. FLT, FET, FMT, Miso, Altanserin, Choline etc. (others are of course possible).
The SynChrom R&D unit is equipped with a compressed air cooled reactor and a 200 W electrical heater. This allows very fast temperature changes in the synthesis reagent solvent. The displayed temperature is the real temperature of the synthesis reagent solvent.
The unit is equipped with very fast, low dead volume, solvent resistant and pressure tight (4 bar) magnetic flipper valves (25, 3 & 2 way). All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built-in pressure sensor continuously displays the actual system (reactor) pressure. This pressure sensor is also used for the automatically gas leakage test after the synthesis unit cleaning procedure.
During the process this sensor also observes the process for unexpected "accidents" with settable warning and shutdown levels.

The reactor is equipped with a special reactor solvent mixing system (without magnetic stirrer) and substitutes the tubing lifting system.
The unit contains a built-in lead shielded housing for the F-trap with a radiation detector for observation, analysis and reporting.
(Can be used also used as the QMA activity cartridge loading position for users without cyclotron).

The target delivery can be done directly to the F-trap or via the water precollecting vial, also equipped with a lead shielded radiation detector.
Close to the reactor a lead shielded radiation detector is installed to monitor the actual delivered activity.
All radiation detectors are used to automatically calculate the yield. (EOB End Of Bombardment , EOS End Of Synthesis, EOP End Of Purification, uncorrected and/or corrected).
The system contains a 18O water recovery vial and on request a second water recovery vial (for flushing the target).
The built-in double membrane, high performance, solvent resistant vacuum pump (40 mbar) allows the fast drying of the solvent.
For purification of the product the instrument contains a build-in semi preparative HPLC system consisting of a 10 ml/min isocratic pump, a 254 nm UV detector, an automatic injector with sample loop for the entire reaction vessel volume, a liquid detector for automatical detection of the injection time (reactor empty).
Dependent on the process the required HPLC separation column is included. Other columns are optionally available.
In front of the HPLC column there is a further lead shielded housing for a cartridge trap (DMSO trap).
The built-in radioactivity flow through detector detects the main peak and the built-in fraction collector automatically collects it.
All detectors are designed for a dynamic range from 10 mCi up to 2 Ci at minimum crosstalk.
The entire unit is tested up to 2 Ci.
A third lead shielded cartridge trap housing is installed after the HPLC product separation and fractioning to allow organic solvent trapping.
All detectors are designed for a dynamic range from 10 mCi up to 5 Ci at minimum crosstalk.
The unit is tested up to 5 Ci.
The unit is controlled by GINA Star software with an almost unlimited flexibility for process optimization.

FMiso synthesis made by Laverman/UMC Nijmegen

Dimensions and data:

Width (without liquid nitrogen tank for cooling, without cold trap):	52cm
Width incl. all equipment:	65cm
Depth:	49cm
Height:	53cm
Weight:	40kg
Main power:	115V or 230V
Power consumption:	200W
Environment humidity:	max. 70% rel
Environment temperature:	10°C - 40°C
Number of valves:	25
Liquid nitrogen cooling Dewar cold trap 1l
Cooling method compressed air
HPLC pump 10 ml/min 400 bar
UV detector 254 nm
Automatic injector with 12 ml sample loop
IR liquid detector
11 Solvent containers ( 4 ml )
1 Magnetic stirrer
Product vessel 20 ml
7 Built-in radioactivity detectors
Reactor pressure sensor
Duran glass reaction vessel 12ml
3 Lead shielded trap cartridge housings
High performance double membrane, solvent resistant vacuum pump (40 mbar)

Further required equipment:

F-

Liquid nitrogen, 1 l/run

Sterile filters

HPLC solvent

Column

Reagents

Helium 2 bar

Compressed air 8 bar

Detailed consumable list available on request

Example Installations:

Reference list on request

Applications for Synchrom:

Download:

Synchrom brochure (PDF)