Synchrom electrophilic substitution F2

 

Synthesis unit for electrophilic substitution

F2 gas target required.
Today 3 electrophilic substitution synthesis processes are implemented:
Others tracers are possible.
Because of the activity trapping the first synthesis step requires a very low temperature. Therefore the SynChrom F2 unit is equipped with a liquid nitrogen cooled reactor and a 200 W electrical heater. This allows very fast temperature changes in the synthesis reagent solvent. The displayed temperature is the real temperature of the synthesis reagent solvent.
The unit is equipped with very fast, low dead volume, solvent resistant and pressure tight (4 bar) magnetic flipper valves. All solvents are transported directly into the reaction vessel without any solvent cross contamination. The built-in pressure sensor continuously displays the actual system (reactor) pressure. This pressure sensor is also used for the automatically gas leakage test after the synthesis unit cleaning procedure.
During the process this sensor also observes the process for unexpected "accidents" with settable warning and The reactor is equipped with a special reactor solvent mixing system (without magnetic stirrer) and substitutes the tubing lifting system.
shutdown levels.
Close to the reactor a lead shielded radiation detector is installed to monitor the actual delivered activity and to automatically calculate the yield. (EOB End Of Bombardment , EOS End Of Synthesis, EOP End Of Purification, uncorrected & corrected) .
For purification the unit contains a built-in semi preparative HPLC system consisting of a 10 ml/min isocratic pump, a 254 nm UV detector, an automatic injector with sample loop for the entire reaction vessel volume and a liquid detector for automatical detection of the injection time (reactor empty).
Dependent on the process the required HPLC separation column is included. Other columns are optionally available.
The built-in radioactivity flow through detector detects the main peak and the built-in fraction collector automatically collects it.
All detectors are designed for a dynamic range from 10 mCi up to 2 Ci at minimum crosstalk.
The entire unit is tested up to 2 Ci.




FDopa synthesis made by Erik de Vries / Groningen NL

Dimensions and data:

Width (without liquid nitrogen tank for cooling, without cold trap): 38cm
Width incl. all equipment: 52cm
Depth: 49cm
Height: 50cm
Weight: 36kg
Main power: 115V or 230V
Power consumption: 200W
Environment humidity: max. 70% rel
Environment temperature: 10°C - 40°C
Number of valves: 12
Liquid nitrogen cooling Dewar 1l (reactor cooling)
Liquid nitrogen cooling Dewar 1l (cold trap)
HPLC pump 10ml/min 400bar
UV detector 254nm
Automatic injector with 3ml sample loop
IR liquid detector
Mass flow detector for F2 flow
4 Solvent containers ( 4 ml )
Product vessel 20 ml
3 Built-in radioactivity detectors (at reactor, flow through detector, product vessel)
Reactor pressure sensor
High performance double membrane, solvent resistant vacuum pump (40 mbar)

Further required equipment:

18F2
Liquid nitrogen, 2 l/run
Sterile filters
HPLC solvent
Column
Reagents
Helium 2 bar
Compressed air 4 bar
Detailed consumable list available on request

Example Installations:


Reference list on request

Publications available on request:

A fully automated one pot synthesis of 9-(4-18F fluoro-3-hydroxymethylbutyl) Guanine for Gene Therapy Studies
Aspects of 6 18F fluoro-L-dopa preparation precursor synthesis preparative HPLC purification and determination of radiochemical purity
Fully automated synthesis module for the high yield one-pot preparation of 6F18 fluoro-L-dopa

Applications for Synchrom:

Download: Synchrom brochure (PDF)